Shisha no Teikoku

The story of Shisha no Teikoku takes place in 19th century Europe, and revolves around John Watson. He is scouted by the government to become a secret agent. However, Watson lives in a world where "Frankensteins"—human corpses that are re-purposed with a false soul in order to use them as laborers—are used to improve industrial development.

Adapted from the novel of the same name.
The novel was also adapted into an anime movie.